Pancreatic stellate cell line
WebJan 1, 2024 · Introduction. Pancreatic fibrosis is a key pathological feature of chronic pancreatitis (CP) and pancreatic ductal adenoma in which the pancreatic stellate cells (PSCs) play an important role 1-4.In the normal pancreas, PSCs are located in periacinar and periductal regions and contain vitamin A in cytoplasmic lipid droplets. WebMay 11, 2024 · Interestingly, hypoxia is known to activate pancreatic stellate cells (PSCs) [10 11].PSCs play a crucial role in the pathogenesis of chronic pancreatitis and pancreatic cancer [].When PSCs transform from a quiescent state into an activated state, they exhibit a myofibroblastic phenotype, express α-smooth muscle actin (α-SMA) and produce …
Pancreatic stellate cell line
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WebHuman Pancreatic CAFs - Stellate Cells These cells promote the malignant process and block immune surveillance. CAFs are thus new drug targets for pancreatic and other … WebApr 1, 2008 · Work by our group and those of others have established that the cells responsible for production of the desmoplastic reaction in pancreatic cancer are pancreatic stellate cells (PSC; refs. 5, 6, 12 ), which are now recognized as key cells in pancreatic fibrogenesis ( 6, 13 – 17 ).
WebPancreatic stellate cells (PSCs) are important pancreatic fibrogenic cells that interact with pancreatic cancer cells to promote the progression of pancreatic ductal adenocarcinoma (PDAC). In the tumor microenvironment (TME), several factors such as cytokines and nucleotides contribute to this interplay. Our aim was to investigate whether there is an … WebConditioned medium from the pancreatic cancer cell lines AsPC-1, BxPC-3, and Panc-1 and human pancreatic stellate cells HPaSteC was used as positive controls. The conditioned media preparations were concentrated down to 5% of their original volume, followed by overnight protein digestion at 37 °C.
WebPancreatic stellate cells are located near the basolateral side of pancreatic acinar cells, around small pancreatic ducts and blood vessels ( Apte et al., 2012 ). A single stellate cell usually has multiple processes … WebPancreatic stellate cells (PSCs) are important pancreatic fibrogenic cells that interact with pancreatic cancer cells to promote the progression of pancreatic ductal …
WebPancreatic stellate cells are activated via paracrine pathways by exogenous factors such as cytokines, oxidant stress, ethanol and its metabolites. Activated PSCs synthesize and secrete endogenous …
WebTargeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro . Fulltext; Metrics; Get Permission; Cite this article; Authors Elechalawar CK , Hossen MN, Shankarappa P, Peer CJ , Figg WD , Robertson JD, Bhattacharya R, Mukherjee P. Received 10 October 2024. shell link filesWebJan 12, 2024 · Pancreatic stellate cells (PSCs), a major component of the tumor microenvironment in pancreatic cancer, play roles in cancer progression as well as drug resistance. Culturing various cells in microfluidic (microchannel) devices has proven to be a useful in studying cellular interactions and drug sensitivity. shell linkedin learningWebFeb 9, 2024 · (A and C) BRD4 was knocked down in an immortalized pancreatic stellate cell line and in primary cancer-associated PSCs, and the effects on BRD4, c-MYC, and FOSL1 mRNA were determined by qRT-PCR (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001. Data were analyzed by 2-tailed unpaired Student’s t test. The effects on BRD4, c-MYC, … shell lines of businessWebSep 30, 2008 · Abstract. Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression. Characterization of the mechanisms … shell link\u0027s awakeningWebNational Center for Biotechnology Information sponge flour mcdougallsWebONLINE INQUIRY PRODUCT REVIEWS Ordering Human Pancreatic Stellate Cells We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote. * Full Name: * Business Email Address: Phone: sponge floss radiusWebThis cell type, the pancreatic stellate cell (PSC, so called because of its star-like appearance in situ) was first reported by Watari ( Watari et al., 1982) in 1982 using electron microscopy of rodent and human pancreas. … shell linnorm spar