WebSep 7, 2016 · This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype defined using the Prosigna (PAM50) Assay. Detailed Description: WebFeb 15, 2024 · Two randomized studies-by the Trans-Tasman Oncology Group (TROG) from Australia [61] and the Radiation Therapy Oncology Group (RTOG study 10-05) [62] are currently accruing patients with DCIS...
BIG 307/TROG 07.01 - DCIS - TROG Cancer Research
WebMar 15, 2024 · The largest and most mature clinical trial of APBI in DCIS is NSABP B-39/RTOG 0413, which randomized 4216 patients, 24% of whom had DCIS, to WBI or APBI (Table 1) [ 38 ]. At 10 years of follow-up, there was no increased risk of IBTR in the DCIS patients who received APBI (HR 1.01 [CI.61−1.68], P = 0.48) [ 38 ]. WebDCIS (BIG 3-07 / TROG 07.01) is an international study that aims to: – investigate if, after breast conserving surgery, higher radiation doses (“boost”) to the part of the breast where the DCIS was, in addition to radiotherapy of the whole breast, would further improve tumour control; ... Canadian Cancer Trials Group (CCTG) European ... direct memory access computer architecture
Randomized trial of short-course radiotherapy versus long-course ...
WebBreast Cancer – Ductal Carcinoma in Situ (DCIS) 1 Candidates for breast conservation therapy: Tumor to breast size ratio allows for acceptable cosmetic result Attempt 2 mm margin No evidence of diffuse microcalcifications on mammography No contraindication to radiation therapy 2Negative net margins: WebMar 3, 2024 · At present, four trials of active surveillance are being conducted to investigate whether watchful waiting is a noninferior alternative strategy for low‐risk DCIS compared with conventional surgery with or without adjuvant irradiation and/or hormonal therapy according to local protocol. 12 - 15 In particular, the COMET (ClinicalTrials.gov … WebMar 15, 2024 · Results of the BIG 3-01/TROG 07.01 trial provide the best evidence to support the use of hypofractionation in pure DCIS. ... The UK/ANZ DCIS trial randomized 1701 women with DCIS treated with lumpectomy in a 2 × 2 factorial fashion to radiation or no radiation and tamoxifen or no tamoxifen. 2 At a median follow up of 12.7 years, ... direct memory access dma controller